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[15] [16] For patients with established cardiovascular disease, chronic kidney disease, or high cardiovascular risk, NICE guidance now prioritises SGLT2 inhibitors as the preferred second-line agents after metformin, rather than either GLP-1 receptor agonists or DPP-4 inhibitors

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Hormonal fluctuations throughout the menstrual cycle can affect how side effects manifest, with some women reporting that nausea is more pronounced during certain phases of their cycle

Weight typically regains (about two-thirds of lost weight within a year)

If it continues, GERD can cause scarring and narrowing of the esophagus and increase a person's risk of esophageal cancer