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Recently, two mechanisms involved in the gut-brain axis have attracted increasing attention due to their role in the pathogenesis and progression of PD, namely, disruption of the composition of microorganisms living in the intestine (intestinal microbiome) and dysfunction of enteroendocrine cells, accompanied by impaired signaling through the GLP-1R [60]

doi: 10.1002/biof.1406 122 WieraGNowakDvan HoveIDziegielPMoonsLMozrzymasJW

Skeletal muscle blood flow in humans and its regulation during exercise

Conversely, macrophages similar to M2 enhance tumor blood vessel formation, immune suppression, cancer cell infiltration, and spread by emitting anti-inflammatory agents such as TGF-, PGE2, and VEGF [61]

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