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In pregnant female rats given subcutaneous doses of 0.1, 0.25 and 1.0 mg/kg/day liraglutide from gestation day 6 through weaning or termination of nursing on lactation day 24, estimated systemic exposures were 0.8-, 3-, and 11-times human exposure at the MRHD of 1.8 mg/day, based on plasma AUC

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Insufficient autophagy may lead to the accumulation of toxic proteins and damaged organelles, affecting normal cell function

Foxa2 controls Pdx1 gene expression in pancreatic -cells in vivo