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20 minutes before beginning testing 3 month old male Sprague Dawley rats were given scopolamine directly into the brain (icv) and 15 minutes later dihexa was given either icv, intraperitoneal ly (ip), or orally

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Instead, only activation of Oxtr -containing neurons, exclusively intestinal IGLEs that detect stretch, potently suppressed food intake, while various subtypes of mucosal ending neurons, which are classically thought to sense gut peptides, had no effect 28

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