Special Populations and Carnitine Deficiency Primary carnitine deficiency is a rare genetic disorder requiring medical supervision and supplementation
This RNA toxicity has been shown to disrupt cellular homeostasis through several pathways, including calcium dysregulation, mitochondrial dysfunction, the enhanced production of ROS, and inflammation [35,53]
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Knockdown of CrAT or CrOT significantly decreased glucose-derived acetyl-CoA to around 50% of the level in controls (Extended Data Fig