Platelets are primarily acknowledged as being essential to primary hemostasis and coagulation
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Clinical trials are underway to study GLP-1 medications for things like heart failure, smoking cessation, alcohol use disorder, nonalcoholic fatty liver disease, and even neurodegenerative conditions like Alzheimers
Because GLP-2 acts through subepithelial myofibroblasts, which are the same cell population implicated in intestinal fibrogenesis, the risk-benefit profile of GLP-2 agonism may differ substantially between mucosal UC, inflammatory ileal CD, and stricturing or penetrating CD phenotypes, and this phenotypic stratification should be a required feature of future trial design
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