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Triple agonists [12] such as GLP-1RA, GIP-RA plus glucagon-RA are in development and may show comparable efficacy in weight loss to tirzepatide by targeting multiple pathways involved in energy regulation [13]

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Breast tumors promote substance P secretion by adjacent sensory neurons, leading to cell death of a small proportion of the tumor cells, subsequent single-stranded RNA release, TLR7-mediated signaling, and metastasis of the surviving tumor cells [250]