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The proof of concept of triagonism dates back to oxyntomodulin, a natural 37-amino acid peptide produced by proglucagon cleavage in intestinal L-cells, which simultaneously activates GLP-1R and GCGR and drives marked weight loss in rodents (Cohen et al., 2003)

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Lpez-Miranda J, Prez-Jimnez F, Ros E, De Caterina R, Badimn L, Covas MI et al (2010) Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jan and Crdoba (Spain) 2008

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