The most cited single result is from Yun and colleagues in 2018, who showed that NLY01, a long-acting PEGylated GLP-1R agonist, blocked the microglia-driven conversion of resting astrocytes into the neurotoxic A1 phenotype in mouse models, a process implicated in neuronal death in both Parkinsons and Alzheimers disease [4]
doi: 10.1016/j.ncl.2021.01.009 [PubMed] 34221552 Kirmani BF, Au K, Ayari L, John M, Shetty P, Delorenzo RJ
The latest available figures show there were more than one million hospital admissions related to alcohol in England in 2023/24
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