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Statistical differences were determined by an unpaired Students t test or two-way ANOVA with the corresponding two-tailed significance determined

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Net Price, by Manufacturer, 2023 Exhibit 212: Average Difference Between List and Net Prices, by Therapeutic Area, 2012 to 2024 Exhibit 213: Total Value of Pharmaceutical Manufacturers Gross-to-Net Reductions for All Brand-Name Drugs, 2021 to 2025 Exhibit 214: Components of Pharmaceutical Manufacturers Gross-to-Net Gap for All Brand-Name Drugs, by Source, 2025 Exhibit 215: Components of Gross-to-Net Bubble, Brand-Name Insulin Products, 2012 vs

This is due to the changes in a hormonal imbalance during puberty

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