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The most extreme cognitive effect of developmental iodine deficiency is irreversible mental retardation

It is likely that these metabolic inefficiencies will be linked to gene SNPs as well as exposure to environmental pollutants

That said, evidence for these findings is not conclusive, and more studies are needed

In agreement with the clinical outcomes, markedly lower plasma histamine and IgE levels, augmented IFN-/IL-4 and IL-10/IL-4 ratios, re-methylation of the IL-4 promoter and de-methylation of the IFN- and Foxp3 promoters were observed [39]

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