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100,101 Clinically, the TruFit Plug (Smith & Nephew, San Antonio TX) is one of the only synthetic osteochondral scaffolds that has been evaluated in patients, 102,103 with a subchondral phase containing calcium sulfate for bone regeneration and an articulating phase that relied on marrow stimulation for cartilage regeneration

Then, they were randomized to receive a high dosage of LC (3 g/day, 1 gr t.i.d, in capsule form) or placebo which contained maltodextrin (3 g/day, 1 gr t.i.d, in capsule form) for 7 days

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Severe gastrointestinal side effects from any GLP-1 medication can cause dehydration, potentially leading to acute kidney injury, so prompt medical review is advised if persistent vomiting occurs

1i, Supplementary Data 1)