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When a compound has no completed human trial, there is by definition no safety data in any subgroup no pregnancy data, no hepatic-impairment data, no interaction data with common metabolic or endocrine medications
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The performance and financial cost of extended absence create motivation to explore off-label options despite regulatory and safety uncertainties
Identification of specific protein amino acid substitutions of extended-spectrum -lactamase (ESBL)-producing Escherichia coli ST131: A proteomics approach using mass spectrometry
Meyer Y, Siala W, Bashandy T, Riondet C, Vignols F, Reichheld JP (2008) Glutaredoxins and thioredoxins in plants
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