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The decrease in NAD + levels may be secondary to a defect in its biosynthesis or to depletion (Imai and Guarente, 2014) and leads to a deficiency in the activities of SIRTs in the nucleus and mitochondria (Chang and Guarente, 2013

Together, these nutrients work within cells, tissues, and organs to improve antioxidant status, normalize metabolic activity, and fine-tune the critical cell signals

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