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The fundamental difference is that GLP-1 agonists eliminate hunger and create a state of pharmaceutical appetite suppression, while AOD-9604 leaves appetite entirely unchanged

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Although epidemiologic studies have shown an association between vascular disease and hyperhomocysteinemia, large randomized controlled trials have shown that lowering homocysteine levels in these patients does not reduce the number of myocardial infarctions or strokes, or improve mortality rates