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10.1080/07388551.2017.1375890 Crit

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Large reports have shown mitochondrial dysfunction is closely related to the progression of kidney diseases (Zhang et al., 2021a)

In addition, these metabolic effects do not appear to be related to their diuretic action or intended pharmacological targets, raising concerns about the long-term metabolic impact of specific diuretics, particularly in vulnerable populations, including those with metabolic syndrome