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Finally, the abundance of gRNAs directed to Notch3 , Pax9 , Kdm6a , Arid1a and Notch2 was not significantly altered between 0 and 3 weeks, suggesting that deleting these genes alone in a wild-type epithelioid culture has a minimal effect on fitness (Fig

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In addition, since iron is heterogeneously distributed across brain regions and cell types (Levi et al., 2024), potential off-target chelation could result in iron depletion in brain regions where iron supports physiological function and consequently affect neuronal and glial metabolism, neurotransmitter synthesis, or cell signaling

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We therefore investigated several important micronutrients, including Vit D, folic acid, VitB12, Ca, K, Mg, P, and Fe in T2DM patients with and without insomnia