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The benefits of Semaglutide include type 2 diabetes management, weight loss, and cardiovascular benefits , making it one of the most effective therapies for improving metabolic health, enhancing insulin sensitivity, and reducing long-term risks associated with obesity and heart disease

When cells respond to oxidative stress, large amounts of highly reactive and toxic ROS are produced and lead to adverse changes in cellular components such as proteins, lipids, and DNA damage [41].Cell membrane is particularly vulnerable to ROS damage due to its high polyunsaturated fatty acids (PUFA), called lipid peroxidation, which is the most significant feature of ferroptosis

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Note that cuprizone application [232] was an extremely high regimen and much higher than those commonly applied to mimic multiple sclerosis in rats [243,244])