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The first hit is characterized by chronic stress-induced release of glucocorticoids and High Mobility Group Box 1 (HMGB1)

In both humans and animal models, acute e-cigarette exposure raises neutrophil recruitment to lung tissue, often influenced by flavorants and sometimes by sex, with some studies noting that cannabinoid-containing aerosols have a greater effect than nicotine-containing ones

NAPQI normally undergoes detoxification by combining with glutathione to form a nontoxic mercapturic acid metabolite that is excreted in the urine

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