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This modification is thought to improve stability and cellular uptake, with the acetyl group being removed once inside cells to release active glutathione

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In experiments with healthy volunteers, dual antagonism during oral glucose or mixed meal ingestion, revealed additive contributions of the two hormones on postprandial glucose excursions as expected, but regarding insulin secretion, removal of the GIP component resulted in the most pronounced reduction of insulin secretion, whereas glucagon secretion was only affected by the GLP-1 component