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Many people find that after an initial "loading" period of 3 to 6 months, they can move to a lower maintenance dose to keep their results stable

Pain was measured using the Knee Injury and Osteoarthritis Outcome Score measurement scale

The dosage is increased in 2.5 mg increments every 4 weeks until reaching the maximum tolerated dose

Other top-performing drugs included the osteoporosis drugs Evenity and Prolia, which brought in $562 million and $727 million, respectively.

BPC-157 is a synthetic pentadecapeptide derived from a partial sequence of a gastric protective protein, studied in preclinical models for its role in cytoprotection, angiogenesis, and connective-tissue repair