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GLP-1 receptor agonists offer a safe, medically supported path to weight loss for individuals who have struggled with traditional methods

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In CRC, combining 5FU with DNA-damaging agents oxaliplatin and/or irinotecan was an empirical choice rather than a rationally designed strategy, and no new combination partners have been added since the introduction of the biological EGFR and VEGF-targeting agents in the early 2000s