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In this regard, in the recent years, new approaches including the recruitment of nanotechnology in targeted topical drug delivery have been considered to overcome these drawbacks and cause optimum clinical response (Salvioni et al., 2021) Therefore, different types of nanoparticles including lipid nanoparticles, nanoemulsion/microemulsion, vesicular nanocarriers, polymeric nanoparticles, nanocrystals, and metal nanoparticles have been used as topical drug delivery systems for melasma management

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