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The reported outcome of this campaign was a candidate that retained agonist activity at amylin/calcitonin-family receptors while displaying a markedly extended pharmacokinetic profile in the authors' preclinical models, and reduced food intake in rodent models following administration

Sun et al., 2018

In the specific in vitro assay measuring synaptogenesis promotion, Dihexa showed activity at picomolar concentrations far lower than concentrations needed for BDNF or other neurotrophic factors to produce comparable effects

Mandatory folic acid fortification has been associated with higher population-wide folate levels, as well as reduced prevalence of neural tube defects, while voluntary programs have been somewhat less effective

A systematic review and meta-analysis of randomised controlled trials