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Mice, which were injected intraperitoneally with lipopolysaccharide (LPS) and intrahippocampal histamine, showed that the histamine had reversed glial reactivity and limited impairments in neurogenesis, suggesting histamine exerts an inhibitory effect against glial activation and the release of proinflammatory molecules

Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease

Immunofluorescence assay The immunofluorescence method referred to our previous study 49

We wouldn't expect the injection to do this because it bypasses the overgrowth

When stool remains in the colon longer, it becomes harder and more difficult to pass