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In cell-based and animal studies, GHRH-receptor agonism (tesamorelin) and GHS-R1a agonism (ipamorelin) have been reported to engage different intracellular signaling cascades that both terminate in growth-hormone secretion, an arrangement investigators have explored for potentially amplified, rather than simply additive, secretory responses

In menopause, this dual action helps restore metabolic flexibilitythe ability to efficiently switch between fat and carbohydrate oxidationwhich estrogen loss compromises

(1) Improve weight loss and loss of appetite Cancer cachexia is one of the common complications in cancer patients, characterized by weight loss, loss of appetite, muscle atrophy, and fatigue

Weight gain is associated with reduced striatal response to palatable food

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