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By contrast, first-time prescribing of AOMs increased 21.7% over the same period, from 0.56% to 0.69%

At the molecular level, sirtuin-1 (SIRT1), a protein dependent on nicotinamide adenine dinucleotide (NAD + ) with key roles in the cellular stress response and energy metabolism, has emerged as a potential regulator in the pathophysiology of FM [7]

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