In drug repositioning it is crucial to understand the disease-drug relationship, for this reason, there are several approaches to address the problem: In silico approaches: in this type of approach, various public databases, clinical trials, and bioinformatic systems are used to identify drug-target interactions (Ekins et al., 2007)
Area ratios of the peak areas of glutarate ( m / z 131.0350 [MH]) to 13 C 9 15 N phenylalanine internal standard ( m / z 174.0989 [MH]), or succinate ( m / z 117.0193 [MH]) to 13 C 4 succinate internal standard ( m / z 121.0328 [MH]) were calculated
JACC Heart
[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Bergmann NC, Lund A, Gasbjerg LS, Meessen ECE, Andersen MM, Bergmann S, Hartmann B, Holst JJ, Jessen L, Christensen MB, et al
DPP-4 rapidly degrades both GLP-1 and GIP (T1/2~4-5 minutes