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Consistent with a link between low selenium and the effects of the GPx1 polymorphisms, in regions endemic for Keshan disease, there was a significant difference in the distribution of alleles in cases and controls, with a greater risk for individuals with the Pro/Leu or Leu/Leu genotypes of developing Keshan disease [36]

Generation and identification of reactive metabolites by electrochemistry and immobilized enzymes coupled on-line to liquid chromatography/mass spectrometry

doi: 10.1016/j.ahj.2011.10.002