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50% stenosis in 1 coronary artery documented by cardiac catheterization or CT coronary angiography

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The drugs, known as GLP-1 receptor agonists, work by mimicking hormones in the gut and the brain to regulate appetite and feelings of fullness

If you've lost less than 5%, options include: Titrating to a higher Zepbound dose Adding a second medication (e.g., metformin, topiramate) Switching to a different GLP-1 or GLP-1/GIP medication Reassessing diet, exercise, and behavioral factors Most patients who switch from Wegovy to Zepbound and titrate to at least 7.5 mg reach the 5% threshold by week 16

Hyperpigmentation Moreover, focal hyperpigmentation involving the face, gingiva, or breasts has been reported