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It is also available as an intravenous infusion for higher bioavailability, and in some cases, as topical creams for skin benefits

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Sildenafil like other PDE5 medications has other health benefits that include treating benign prostate hyperplasia (BPH), reducing blood pressure, and even increasing blood flow for a better pump in the gym

The cGMP that is produced via NO activation of soluble guanylate cyclase (sGC) in this tissue is degraded by a specific cyclic nucleotide phosphodiesterase (PDE) identified as PDE5A