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Conversion of calcidiol to its biologically active form, calcitriol, occurs through the activity of a specific 25-hydroxyvitamin D 3 1--hydroxylase (commonly just called 1--hydroxylase) present in the inner mitochondrial membrane of cells of the proximal convoluted tubules of the kidneys, and in several extrarenal sites such as in keratinocytes, macrophages, and placenta

Tgm2-catalyzed covalent cross-linking of IB drives NF-B nuclear translocation to promote SASP in senescent microglia

Both substances can also be administrated as supplements from the outside

K.LincyJ.et al (2023)

Because these injections are not regulated by the FDA in the same way as medications, there can be variations in quality and composition