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But honestly, the short answer doesn't do justice to the science behind it or the potential consequences of getting it wrong

The gastrointestinal tolerability profile is an important consideration when initiating therapy and counseling patients about what to expect during treatment

A recent systematic review and meta-analysis demonstrated increased small intestinal and whole gut permeability in MAFLD patients, even if this was not confirmed in all individual studies (134, 140, 141)

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Kyle Simmons and Joseph Schacht - are currently leading independent randomised trials to uncover the power of second-generation semaglutides for addiction treatment