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When a supplement is manufactured without strict quality controls, it may contain fillers, synthetic binders, or heavy metal contaminants that irritate the body

In the small intestine, detached from the R binder protein, the free B 12 binds to intrinsic factor from the stomachs parietal cells, allowing for absorption in the terminal ileum [33]

The potency of oral medications diminishes as they travel through the digestive tract, and absorption is further slowed by the transit time through the stomach and intestines prior to entering the bloodstream

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