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Studies suggest that a significant proportion of long-term metformin users may develop biochemical B12 deficiency, though estimates vary widely depending on the population studied, the duration of use, and the B12 threshold applied

The former dismutates peroxides (e.g

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Dihexa is not currently regulated or banned by major doping agencies like WADA, but its novel mechanism and unapproved status underscore the need for careful clinical evaluation before widespread use

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