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Legionella effectors, including SidF, inhibit host apoptosis by antagonizing pro-apoptotic Bcl-2 family proteins, allowing prolonged intracellular survival ( 3.4 Mitochondrial ROS and metabolic reprogramming in bacterial infection Bacterial infections frequently induce mtROS as a byproduct of disrupted ETC function or calcium overload
Interestingly, N-acetylcysteine (NAC) which readily enters cells to convert to cysteine for GSH generation, is an important antioxidant 13
Evidence: Research supports that glutathione can improve skin elasticity and reduce the visible signs of aging by protecting against oxidative damage and supporting collagen production
Discussion By nature, an orally ingested health supplement is only efficacious if it can adequately cross the bloodgut barrier and enter into the circulatory system
D., Aladag, T., Duran, I
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