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445 participants with obesity and knee osteoarthritis, without diabetes, randomized 1:1:1 to 9mg, 12mg, or placebo over 68 weeks

However, GLP-1RAs also have separate effects on appetite regulation mediated by actions on central nervous system centers that result in weight loss 15,16

Whether youre an addiction specialist, someone affected by substance misuse, or simply curious about advancements in addiction medicine, this guide offers a helpful overview

M., Han, J

Participants are randomly assigned to receive either retatrutide or a matching placebo injection, and neither the patients nor the investigators know who is receiving which treatment until the study is complete