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Viral protein, nsp14 , interacts with the catalytic domain of Sirt1, dysregulates Nrf2/HO1 axis, and impairs host antioxidant defense 53

The Role of the Liver The liver is the primary site for glutathione production and use

Mesenchymal stem cells (MSCs) have been employed in both clinical and experimental settings to mitigate severe immune-linked diseases utilizing their immunomodulatory properties

These genes, such as TNF, pro-IL-1, IL-6, IL-8, IL-12, IB, activating transcription factor 3 (ATF3), zinc finger CCCH-type containing 12A (ZC3H12A), and tristetraprolin, are implicated in antimicrobial defense (e.g., defensins, lipocalins), inflammatory responses, metabolic changes, and tissue repair (e.g., secretory leukocyte peptidase inhibitor [SLPI])