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The necessary bridge from animal pharmacology to human safety and effectiveness has not been established
Meanwhile, AOD-9604's mechanism skips insulin pathways entirely, acting directly on adipocyte receptors to trigger lipolysis without the glucose side effects that make full-length growth hormone problematic for metabolic research
Drugs much smaller have low oral bioavailability due to difficulty in getting through the gut wall Even if AOD9604 was only a small peptide, it would still be susceptible to enzymatic degradation in the gut, being derived as it is from a naturally occurring protein12
This peptide has also been studied as a potential anti-inflammatory treatment, and research suggests it may show promise in treating skin conditions like rosacea (27)
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