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Cardinal Health reports sales boost from GLP-1 medications GLP-1 prescriptions grew more than 2,000% from 2019 to 2022
Its cyclic structure biases it toward the Gq/11 intracellular signaling pathway rather than the Gs pathway, which is why it suppresses appetite without triggering the cardiovascular side effects that sank earlier MC4R agonists in clinical development
The glucagon receptor component of retatrutide raises specific safety questions that require further investigation
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