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All-cause mortality Compared with placebo, tirzepatide and the GLP-1RA class significantly reduced the risk of all-cause mortality (HR 0.74, 95% CI 0.650.83 and HR 0.88, 95% CI 0.830.92, respectively)

They found that individuals within the carnitine supplementation group preserved lean body mass and upper arm strength, while those without supplementation did not

The anti-PCSK9 antibody Ab#2 was affinity matured by rational design using a structure homology model of the mAb in complex with human PCSK9 to generate the optimised version Ab#2.1, which should deliver robust PCSK9 suppression at lower doses than Ab#2

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