These PUFAs (and to a lesser extent the PUFAs of cholesterol esters and triglycerides in the lipoprotein core) are highly vulnerable to oxidation by free radical species, particularly hydroxyl radicals ( OH)
Moreover, we summarized the pharmacological progress of targeting ferroptosis in DKD in the hope of providing new therapeutic strategies for patients with DKD
However, long-term administration of GCs at high doses is frequently associated with severe adverse effects, in particular, metabolic disorders and atrophic effects, including musculoskeletal side effects (glucocorticoid-induced osteoporosis (GIO), osteonecrosis, myopathy), disorders of carbohydrate and fat metabolism (diabetes mellitus, dyslipidemia, obesity), gastrointestinal, cardiovascular effects (Fig
Chin Med 15 , 88 (2020)
Thus, each GSH-depleting agent induces different responses in the distribution of cellular GSH when fibroblasts were proliferating