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The consequences of Cd hitting mitochondria include oxidative stress, the production of ROS, the start of apoptosis, the mutation of MTs-DNA, the modification of gene expression, the inhibition of respiratory chain complexes, the reduction of ATP synthesis, and the modification of endo-mitochondrial conductivity

Indeed, high reductive stress can paradoxically elevate superoxide levels via Glutathione Reductase (GSR) and Thioredoxin Reductase (TrxR) due to impaired electron flow caused by inhibitors (65)

& Naesby, M

Folate deficiency In the case of a folate deficiency, the entire folate cycle comes to a standstill with corresponding consequences on the methionine cycle and the biopterin cycle