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[1] [2] Native GLP-1 is broken down within minutes by an enzyme called DPP-4, which is precisely why pharmaceutical GLP-1 receptor agonists were engineered to resist that breakdown and last far longer

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Fernandez-Rhodes LE, Kokkinis AD, White MJ, Watts CA, Auh S, Jeffries NO, Shrader JA, Lehky TJ, Li L, Ryder JE, Levy EW, Solomon BI, Harris-Love MO, La Pean A, Schindler AB, Chen C, Di Prospero NA, Fischbeck KH

No association of the 5 promoter region polymorphism of CYP17 gene with prostate cancer risk

These considerations highlight the importance of evaluating supplements within a clinically integrated framework rather than as isolated adjuncts