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By binding to these receptors, estrogens and estrogen-like molecules modulate cell proliferation (Pisano et al., 2017

Lameire N, Kruse V, Rottey S

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Reduced FH enzyme activity leads to the accumulation of the cellular level of fumarate, and fumarate can undergo a reaction with cysteine residues of proteins, which is called succination ( FH -knockout ( FH /- ) cells are sensitive to ferroptosis, and such sensitivity is attributed to dysfunctional GPX4 ( FH /- cells, and the reaction reduces the activity of GPX4 ( Infectious disease The skin is in some sense a defense organ representing an essential barrier against external microbial insults

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