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An increase in BBB permeability is commonly observed via enhanced accumulation of blood-derived proteins in the brains of post-mortem AD patients [101] and supported by the reduction of tight junction proteins [102]

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Skipping doses can interrupt the gradual metabolic improvements

Subsequently, 1 M dihydroethidium (DHE) was added to the medium and further incubated for 30 min

First, since this is a narrative review rather than a systematic review, the selection of studies evaluated in this review may have introduced biases due to the limited availability of research articles on certain aspects of the topic