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A rare complication of this deficiency is optic neuropathy which results in progressive, bilateral, painless vision loss

Authors reported small statistically significant differences in weekly weight loss at the 1 mg dose with a non-linear dose response, but the abstract data has not been published in full peer-reviewed form

GH increases blood glucose and can cause insulin resistance with chronic use

This happens because certain MTHFR mutations (C667T and A129C) lower the amount of active folate being produced in the body, and the use of vitamin B12 requires the active form of folate

Afterward, the dosage can be reduced to 2-3 vials per week