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The fatty acid moiety and the linking chemistry to GLP-1 were the key features to secure high albumin affinity and GLP-1 receptor (GLP-1R) potency and in obtaining a prolonged exposure and action of the GLP-1 analogue

These hexapeptides showed appreciable GH-releasing potency but co-stimulated adrenocorticotropic hormone (ACTH), cortisol, and prolactin, a lack of selectivity that would become the central design problem for later compounds in the class

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