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AD patients also display additional biomarkers including cerebrovascular pathology and vascular dysfunctions, decreases in cerebral blood flow, cerebrovascular reactivity, and neurovascular coupling, leading to brain deficits in oxygen and nutrient delivery [4,5]

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If GI side effects are manageable, add cagrilintide at 0.25 mg weekly starting in week 5, while simultaneously increasing retatrutide to 2 mg as per its standard titration