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Current evidence suggests creatine is generally well-tolerated in people with type 2 diabetes who have normal kidney function

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This common concern affects many patients starting glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), or dulaglutide (Trulicity) for type 2 diabetes or weight management

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As a result, GL-1RAs play a role in reversing or improving VSMC dysfunction by suppressing VSMCs proliferation, migration, apoptosis, as well as inhibiting VSMC phenotypic switching, especially inhibiting osteoblastic differentiation

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